Exploring ESPD55: The Next Chapter in the Ethnopharmacologic Search for Psychoactive Drugs
In 2022, the McKenna Academy of Natural Philosophy hosted the third conference of the Ethnopharmacologic Search for Psychoactive Drugs (ESPD) symposium—ESPD55, marking 55 years since the original landmark conference in 1967 held in San Francisco sponsored by the U.S. Department for Mental Health. The third conference brought together some of the most respected voices in ethnobotany, pharmacology, anthropology, and Indigenous medicine to explore the evolving science and cultural relevance of psychoactive plant medicines.
An essential reference on the research and social impacts shaping the future of psychedelic science.
Synergetic Press is proud to publish the proceedings of the 2022 conference where over thirty papers were presented covering a wide spectrum of topics, including ancient and contemporary uses of psychoactive substances, the intersection of traditional knowledge and modern science, pharmacology, conservation, law and policy, and the cultural and spiritual significance of these compounds.
The conference program was organized into thematic “spheres”—Ethnosphere, Phytosphere, Mycosphere, and Sonosphere—highlighting the diverse ways psychoactive plants, fungi, and even sound have shaped human societies and consciousness. Presentations ranged from archaeological evidence of ancient plant use and indigenous perspectives on coca and ayahuasca, to modern neuroscience, sound as a psychoactive medium, and the evolving legal landscape for psychedelics.
ESPD55 also fostered collaboration between established experts and emerging voices, emphasizing the importance of biocultural conservation, respect for indigenous wisdom, and responsible innovation in psychedelic science.
With contributions from luminaries like Dennis McKenna, Paul Stamets, David Nutt, Monica Gagliano, Wade Davis, and many more, this publication will serve as a vital resource for researchers, practitioners, and anyone curious about the profound role psychoactive plants play in human health, consciousness, and culture.
Stay tuned for the release of ESPD55, a co-creation between Synergetic Press and the McKenna Academy for Natural Philosophy
Stay in the Loop — Please leave us your contact details, we will send you information about the release of ESPD55 this Summer.
Speakers and Participants in the Ethnopharmacologic Search for Psychoactive Drugs Conference, hosted by the Mckenna Academy, May 2022
